[徵paper] ANA test
South Med J. 2012 Feb;105(2):100-4. doi: 10.1097/SMJ.0b013e31824551a1.
Using the antinuclear antibody test to diagnose rheumatic diseases: when does
a positive test warrant further investigation?
Volkmann ER, Taylor M, Ben-Artzi A.
Division of Rheumatology, David Geffen School of Medicine, University of
California-Los Angeles, Los Angeles, CA 90095-1670, USA.
Abstract
The anti-nuclear antibody (ANA) test is ordered commonly as a screening test
for rheumatic diseases. Although ANA positivity is highly sensitive for
certain rheumatic diseases, the presence of ANA is nonspecific and can be
associated with numerous nonrheumatic factors, including environmental
exposures, malignancies, drugs, and infections. This article describes a
practical approach for physicians when evaluating patients using a positive
ANA test. In the absence of connective tissue disease symptoms, the ANA test
has minimal clinical significance in diagnosing rheumatic diseases.
Understanding how to use ANA test results appropriately may reduce
unnecessary referrals and costly workups.
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