Re: [問題] 請問loading Depakine或Dilantin~

看板Nurse (護理人員)作者doctoja ( )時間17年前 (2008/03/27 23:00)推噓1(1推 0噓 1→)

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※ 引述《doctoja ( )》之銘言： : ※ 引述《asami (喜歡浩秀not湖水)》之銘言： : : as title : : 如果要loading Depakine或Dilantin的話 : : 學姐們會在bag裡面稀釋多少水??然後給多少的速度?? : : 我的師父教我→Depakine大概是100ml然後給200ml/hr的速度 : : Dilantin比較容易allergy~所以速度可以慢一點 : : 單位資深學姐→loading這類的藥物滴速應該要快一點 : : 因為第一次的loading是為了增加體內濃度的這樣 : : 所以Depakine應該是50ml然後給500ml的速度 : : 不過因為Dilantin容易alergy~所以也是說速度可以慢一點 : : 請問到底哪個才對啊???? : : 藥典只有提到他T1/2跟代謝機轉之類的 : : 沒講到給藥速度耶~~@@" : : 先謝謝回答我的學姐喔!!感激不盡啊!! : 查了micromedex : #Dilantin : Intravenous : (adults) max infusion rate 50 mg/min : (neonates) max infusion rate 1 to 3 mg/kg/min (max 50 mg/min) : avoid continuous infusion : flush line with saline following infusion to avoid local venous irritation caused by alkalinity of solution : inject directly into a large vein through a large-gauge needle or IV catheter : #Depakine : A suggested dose to begin therapy in adults is up to 10 mg/kg by intravenous : injection over 3 to 5 minutes followed by intravenous infusion, as necessary, : up to a maximum of 2.5 g daily. The usual intravenous dose for children is : in the range of 20 to 30 mg/kg daily. If doses in excess of this are required : , plasma-valproate concentrations must be monitored, and if the dose exceeds : 40 mg/kg daily, clinical chemistry and haematological parameters should also : be monitored. 總結一下: Status epilepticus: 10-15 mg/kg IV loading dose (not to exceed 50 mg/min), followed by maintenance doses of 100 mg ORALLY OR IV every 6-8 hr -- ※ 發信站: 批踢踢實業坊(ptt.cc) ◆ From: 118.171.136.47