[申覆] 醫學五 50題
醫學五
<50題>Beckwith-Wiedemann Syndrome可能合併何種腫瘤?
A).lymphoma B).neuroblastoma C).Wilm's tumor D).hepatoblastoma
答案: C
建議答案: B或C 或 D
佐證資料:
GeneReviews
Edited by Roberta A Pagon, Editor-in-chief, Thomas D Bird, Cynthia R Dolan,
and Karen Stephens.
Seattle (WA): University of Washington, Seattle; 1993-.
Copyright c 1993-2011, University of Washington, Seattle. All rights
reserved.
Beckwith-Wiedemann Syndrome - GeneReviews
Neoplasia. Children with BWS have an increased risk of mortality associated
with neoplasia, particularly Wilms tumor and hepatoblastoma, but also
neuroblastoma, adrenocortical carcinoma, and rhabdomyosarcoma. Also seen are
a wide variety of other tumors, both malignant and benign [Cohen 2005]. The
estimated risk for tumor development in children with BWS is 7.5% with a
range of risks estimated between 4% and 21% [Sotelo-Avila et al 1980,
Wiedemann 1983, Pettenati et al 1986, Elliott et al 1994, Weng et al 1995,
Schneid et al 1997, DeBaun & Tucker 1998, Cohen 2005, Tan & Amor 2006]. This
increased risk for neoplasia seems to be concentrated in the first eight
years of life. Tumor development in affected individuals older than age eight
years, although uncommon, has been reported.
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