Re: [問題] 5-Fu和Cisplatin會打在同一個bag裡嗎？

看板pharmacist (藥學生/藥師)作者liban (錄取率創新高改行賣雞排)時間14年前 (2011/08/14 02:01)推噓2(2推 0噓 1→)

留言3則, 3人參與討論串2/2 (看更多)

以下來自micromedex Cisplatin-Fluorouracil Y-Site Compatible Admixture Incompatible Syringe Compatible Admixture Detail： Cisplatin 0.2 mg/mL Fluorouracil 1 mg/mL Incompatible In Normal saline- Sodium chloride 0.9% Physical Compatibility: Physically compatible. No haze or particulate formation, color change, or gas evolution. Chemical Stability: Chemically unstable. About 10% cisplatin loss occurred in 90 minutes and about 25 to 30% loss occurred in 3 to 4 hours. No fluorouracil loss occurred within the study period. Storage: Room temperature of 24 to 26 °C exposed to fluorescent light and protected from light. Study Period: Up to 24 hours. Method: Visual observation and stability-indicating HPLC analysis of drug concentrations. Container: Polyvinyl chloride (PVC) bags. Ref:Stewart CF, Fleming RA: Compatibility of cisplatin and fluorouracil in 0.9% sodium chloride injection Am J Hosp Pharm: 1990 47: 1373-7 ------------------------------------------------------------------------------ Cisplatin 0.5 mg/mL Fluorouracil 10 mg/mL Incompatible In Normal saline- Sodium chloride 0.9% Physical Compatibility: Physically compatible. No haze or particulate formation, color change, or gas evolution. Chemical Stability: Chemically unstable. About 10% cisplatin loss occurred in 90 minutes and about 25 to 30% loss occurred in 3 to 4 hours. No fluorouracil loss occurred within the study period. Storage: Room temperature of 24 to 26 °C exposed to fluorescent light and protected from light. Study Period: Up to 24 hours. Method: Visual observation Container: Polyvinyl chloride (PVC) bags. Ref:Stewart CF, Fleming RA: Compatibility of cisplatin and fluorouracil in 0.9% sodium chloride injection Am J Hosp Pharm: 1990 47: 1373-7 ----------------------------------------------------------------------------- Cisplatin 0.5 mg/mL Fluorouracil 10 mg/mL Incompatible In Normal saline- Sodium chloride 0.9% Physical Compatibility: Not reported. Chemical Stability: Chemically unstable. About 80% loss of cisplatin occurred in 24 hours. Storage: Room temperature protected from light. Study Period: 15 days. Method: HPLC analysis of drug concentrations. Container: Polyvinyl chloride (PVC) plastic bags. Ref:Lokich J, Anderson N, Bern M, et al: Combined floxuridine and cisplatin in a fourteen day infusion Cancer: 1988 62: 2309-12 ※ 引述《wylscott (林佳樹)》之銘言： : 最近有遇到這個例子 : 雖然我和幾位藥師覺得怪怪的 : 因為Cisplatin是酸性 : 而5-Fu是鹼性 : 但是查了Micromedex : 並沒有Drug-Drug interaction : 不過醫師堅持這樣用我也沒辦法 : 請問有其他在醫院的同仁們有聽過這種用法嗎？ : 這樣藥效會不會減弱呢？ : 會的話 : 請問你們認為影響的機轉是什麼？ : 麻煩解惑一下謝謝～ -- ※ 發信站: 批踢踢實業坊(ptt.cc) ◆ From: 111.80.40.47