[Ask ] Why would the anti-inflammatory drug cause ulcer

看板EngTalk (全英文聊天)作者 (.)時間17年前 (2008/11/27 22:47), 編輯推噓4(4016)
留言20則, 3人參與, 最新討論串1/1
I've read a news article about Barbara Bush, a former first lady of the United States, who underwent a surgery to fix her perforated duodenum ulcer. It's suspected that the anti-inflammatory drug could cause this-- uncommon but not unheard of. Why is that? What is the likely mechanism of it? -- ※ 發信站: 批踢踢實業坊(ptt.cc) ◆ From: 114.44.147.31

11/27 23:20, , 1F
most NSAIDS (Non Steroidal Anti Inflammatory Drugs)
11/27 23:20, 1F

11/27 23:21, , 2F
are COX (Cyclooxygenase) inhibitors
11/27 23:21, 2F

11/27 23:21, , 3F
There are 2 dominant COX forms (human) COX1; COX2
11/27 23:21, 3F

11/27 23:24, , 4F
in short, COX1 is responsible for blood/mucosal
11/27 23:24, 4F

11/27 23:25, , 5F
regulation, COX2 is for Inflammation
11/27 23:25, 5F

11/27 23:28, , 6F
-------------------------------------------
11/27 23:28, 6F

11/27 23:29, , 7F
So why not just inhibit COX2 ?
11/27 23:29, 7F

11/27 23:31, , 8F
at 2004, a COX2 specific(~30 fold)inhibitor Vioxx
11/27 23:31, 8F

11/27 23:33, , 9F
was recalled from the market, no patients had ulcer
11/27 23:33, 9F

11/27 23:34, , 10F
but almost half suffered myocardial infarction...
11/27 23:34, 10F

11/27 23:37, , 11F
Merck, was hurt bad
11/27 23:37, 11F

11/27 23:52, , 12F
the more you are saying , the more vague I fell. XD
11/27 23:52, 12F

11/27 23:54, , 13F
okay my wrong. The most popluar anti inflammatory
11/27 23:54, 13F

11/27 23:55, , 14F
is catagorized as NSAIDS
11/27 23:55, 14F

11/27 23:56, , 15F
It reduces both COX1 and COX2 in the body ^drugs
11/27 23:56, 15F

11/27 23:57, , 16F
If you need Pain relief, you only need to stop COX2
11/27 23:57, 16F

11/27 23:58, , 17F
Instead, COX1 is affected as well, causing stomach-
11/27 23:58, 17F

11/27 23:59, , 18F
problems
11/27 23:59, 18F

11/28 01:00, , 19F
chemistry always does the trick better than count-
11/28 01:00, 19F

11/28 01:00, , 20F
ing sheeps.
11/28 01:00, 20F
文章代碼(AID): #19BhCBKN (EngTalk)
文章代碼(AID): #19BhCBKN (EngTalk)