Re: [問題] NSAID藥物
看板pharmacist (藥學生/藥師)作者smeliz (i see...)時間17年前 (2008/02/03 12:50)推噓0(0推 0噓 1→)留言1則, 1人參與討論串3/3 (看更多)
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以下引自Facts and Comparisons 4.0 (online):
NONSTEROIDAL ANTI-INFLAMMATORY AGENTS
Warnings/Precautions
Studies have shown that patients with a history of peptic ulcer disease
or GI bleeding and who use NSAIDs, have a greater than 10-fold risk for
developing a GI bleed than patients with neither of these risk factors.
In addition, treatment with oral corticosteroids or anticoagulants,
longer duration of NSAID therapy, smoking, alcoholism, older age, and
poor general health status contribute to an increased risk for a GI bleed.
High-dose NSAIDs probably carry a greater risk of these reactions, although
controlled clinical trials generally do not show this. In considering the
use of relatively large doses(within the recommended dosage range),
sufficient benefit should offset the potential increased risk of GI
toxicity. To minimize the potential risk for an adverse GI event, use the
lowest effective dose for the shortest possible duration. For high-risk
patients, consider alternate therapies that do not involve NSAIDs.
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※ 編輯: smeliz 來自: 164.107.209.5 (02/03 12:56)
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