[徵人] 成大呂佩融老師誠徵博士後
Project：
PIN1BPs and PIN1 protein interaction and functional regulation of Pin1
3 year post-doctoral positions are currently open for experienced researchers
to work in the above projects funded by Taiwan National Science Council.
The selected candidate will study the PIN1BPs and the functional regulation
of some WW domain-containing proteins involved in the cancer and
Alzheimer’s disease.
Profile:
PhD degree in Molecular or Cell Biology, Biochemistry, Medicinal Chemistry
or related areas.
Methodological approaches:
Epithelial cell culture; genetic engineering techniques; protein analyses;
general molecular biology and biochemistry manipulations; advanced cell biology
(immunofluorescence microscopy) techniques; tumor xenograph model,
soft agar colony fomration assay, protein-protein interaction, kinase assay.
Place of Work:
Department of Clinical Medicine, National Cheng-Kung University, Tainan, Taiwan.
Starting date: September 1st 2008
Duration:
These positions are offered for one year period, renewable for another 2 years.
Amount: ~28,000 US $/ year
Requirements:
Previous research experience demonstrated by scientific peer-reviewed
publications.
Applications:
Send by mail (address below) CV including publication list, motivation letter
and two recommendation letters. Candidates should indicate availability for
a telephone interview.
Prof. Frank Pei-Jung Lu
Graduate Institute of Clinical Medicine, National Cheng Kung University,
Tainan, Taiwan.
Tel: +886-6-2353535 x 4415
Fax: +886-6-3028162
Email: pjlu2190@mail.ncku.edu.tw
Website: http://clinmed.med.ncku.edu.tw/teacher_a.php?id=12
Selected publications:
P.J. Lu, X. Z. Zhou, M.H. Shen and K.P. Lu (1999) Function of WW Domains
as Phosphoserine- or Phosphothreonine-Binding Modules, Science, 283, 1325-1328.
P.J. Lu, G. Walf, X. Z. Zhou, P. Davies and K.P. Lu (1999) The Prolyl Isomerase
Pin1 Restores the Biological Function of Alzheimer-associated Phosphorylated
Tau, Nature, 399, 784-788.
P.J. Lu, X. Z. Zhou, Y.C. Liou,, J.P. Noel, and K.P. Lu (2002) Critical role of
WW domain phosphorylation in regulating phosphoserine binding activity and Pin1
function. J. Biol Chem., 277, 2381-2384.
L. W. Chen, H.L. Huang , I. T. Lee , C.M. Hsu, P. J Lu (2006) Thermal
Injury-Induced Priming Effect of neutrophils is TNF and p38 Dependent. Shock.
26, 69-76.
L. Pastorino* , A. Sun*, P.J. Lu*, M. Balastik, G. Finn, G. Wulf G, SH. Li,
X. Li, Xia W, LK Nicholson. KP Lu. (2006) The prolyl isomerase Pin1 regulates
amyloid precursor protein processing and Abeta production. Nature. 440, 528-534
* equal contribution
P.I. Hsu, C.H. Chen, C. S. Hsieh, W.C. Chang, K.H. Lai, G.H. Lo, P.N. Hsu,
F.W. Tsay, Y.S. Chen, M. Hsiao, H.C. Chen, P.J. Lu (2007) 1-antitrypsin
precursor in gastric juice is a novel biomarker for gastric cancer and ulcer.
Clin Cancer Res. 13, 876-883
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