Re: [問題] Rocephin vs 鈣
看板pharmacist (藥學生/藥師)作者sharkimage (生日那天的甜蜜 ~)時間16年前 (2009/06/14 14:45)推噓5(5推 0噓 4→)留言9則, 3人參與討論串2/2 (看更多)
Medscape April 14, 2009 — Ceftriaxone Can Be Administered With Calcium
-Containing Products in Certain Patients
Ceftriaxone can now be administered concomitantly with calcium-containing
products in patients older than 28 days but remains contraindicated in
neonates, the US Food and Drug Administration (FDA) announced today.
The announcement updates a previous recommendation that ceftriaxone and
calcium-containing products should not be administered within 48 hours of
one another, regardless of patient age.
The FDA requested that the manufacturer of ceftriaxone conduct in vitro
studies to investigate whether ceftriaxone-calcium precipitates when
ceftriaxone and calcium-containing products are mixed in vials and in
infusion lines, according to an alert from MedWatch, the FDA's safety
information and adverse event reporting program.
Studies were conducted in plasma from adults and neonates at normal and
greater than physiologic concentrations.
According to the FDA's information for healthcare professionals,
ceftriaxone and calcium-containing products may be used concomitantly in
patients older than 28 days using precautionary steps because "the risk of
precipitation is low in this population."
Precautionary steps include sequential administration in patients older
than 28 days provided that the infusion lines are thoroughly flushed between
infusions with a compatible fluid.
In addition, ceftriaxone must not be administered simultaneously with
intravenous calcium-containing solutions via a Y-site in any age group.
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