Re: [問題] hypersensitive site

看板Biology (生物學)作者 (chickenman)時間18年前 (2007/12/17 02:33), 編輯推噓0(000)
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※ 引述《nnf (嗯嗯福)》之銘言: : 【問題】: : 請問euchromatin代表的是含有較多hypersensitive site嗎? : heterochromatin則是由於許多promoter region is packaged into nucleosomes所以造成 : 有較多不活化區域嗎? The differences between euchromatin and heterochromatin are the packageing status of nucleosome. For euchromatin, the nucleosomes get on-off the DNA frequently. For heterochromatin, the nucleosomes stay on DNA and don't get off. Some other mechanisms, such as DNA methylation can make covalent modification, and keep the nucleosome saty on DNA all the time. : 【問題起因】: : 最近在讀有關染色體 : 讀到這裡整個都混亂了 : 說什麼大部分的轉錄皆位於hypersensitve site : 而hypersensitive site則是沒有nucleosome包裝的染色體 : 然後 大部分active gene位在euchromatin : 可是euchromatin不是也有nucleosome包裝嗎???... : 搞的一頭霧水... : 【個人看法】: : 好難 As for gene expression, the transcription factors will compete off the nucleosome. similar situation will happen when DNase tries to digest DNA, so those places become "HYPER-sensitive". Hope this can hlep you. -- ※ 發信站: 批踢踢實業坊(ptt.cc) ◆ From: 140.120.241.61
文章代碼(AID): #17PM-JXH (Biology)
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文章代碼(AID): #17PM-JXH (Biology)