[英中] 新聞翻譯一篇，歡迎前輩們指正~

看板Translation (筆譯/翻譯)作者hsuanjuchen (雪倫)時間12年前 (2012/07/27 13:43)推噓7(7推 0噓 73→)

留言80則, 9人參與討論串1/1

這次是有關醫學科技的新聞，歡迎大家的指正與意見~ 新聞來源為BBC News。註：我想不出"copy of the gene"(copies of a gene) 怎麼翻會比較好… 有查到可能是"基因拷貝組"但似乎沒有比較"正確"的名字？ Gene therapy nears approval in Europe 歐洲即將通過基因療法 Europe is on the cusp of approving a gene therapy for the first time, in what would be a landmark moment for the field. 歐洲將首次通過基因療法，這會是醫藥界的重要里程碑。 Gene therapies alter a patient's DNA to treat inherited diseases passed from parent to child. 基因療法可改變病患的DNA，以治療遺傳自雙親的疾病。 The European Medicines Agency has recommended a therapy for a rare genetic disease which leaves people unable to properly digest fats. 歐洲藥物管理局已提出一項療法，適用於身體無法適當分解脂肪的罕見遺傳性疾病患者 The European Commission will now make the final decision. 歐盟委員會將做出最後的決定。 The idea of gene therapy is simple: if there is a problem with part of a patient's genetic code hen replace that part of the code. 基因治療的概念很簡單。如果患者有某部分的遺傳密碼出錯了，將出錯的部分替換即可。 The reality has not been so easy. In one gene therapy trial a US teenager, Jesse Gelsinger, died, and other patients have developed leukaemia. 但實務上沒這麼容易。在一次基因療法的試驗中，一位名叫傑西蓋希爾的美國青少年因此死亡，而另一名患者則罹患白血病。 There are no gene therapies available outside of a research lab in Europe or the US. 基因療法只在歐洲和美國的實驗室裡執行。 Gene change 基因改造 The European Medicines Agency's Committee for Medicinal Products for Human Use has considered the use of Glybera to treat lipoprotein lipase deficiency. 歐洲藥物管理局的人類藥物組考慮利用Glybera治療脂蛋白酯酶缺乏症。 One in a million people have the deficiency. They have damaged copies of a gene which is essential for breaking down fat. 每一百萬人就有一人罹患此病。這種病會破壞分解脂肪基因組的複製， It leads to fat building up in the blood, abdominal pain and life-threatening pancreatitis (inflammation of the pancreas). 導致脂肪在血液中堆積、腹部疼痛，和引發危及生命的胰臟炎。 The only way to manage the condition is by having a very low-fat diet. 唯一控制病情的方法就是極端的低脂飲食。 The therapy uses a virus to infect muscle cells with a working copy of the gene. 基因療法利用病毒攜帶可用的基因複製組感染肌肉細胞。 It was recommended for patients with severe pancreatitis, who cannot control the disease through diet. 此療法建議用於患有嚴重胰臟炎的病人，因為他們無法藉由飲食控制病情。 'Afraid of a normal meal' 懼怕正常飲食 The manufacturer, UniQure, said the decision was a "major breakthrough" for patients and medicine as a whole. 製藥商UniQure表示，總體而言，這項決定對病人和醫藥界都是一項重大的突破。 UniQure chief executive officer Jorn Aldag said: "Patients with lipoprotein lipase deficiency are afraid of eating a normal meal because it can lead to acute and extremely painful inflammation of the pancreas,often resulting in a visit to intensive care." UniQure執行長喬恩艾達說：「脂蛋白酯酶缺乏症患者不敢擁有正常的飲食，因為會導致急性、異常疼痛的胰臟炎，且通常到最後都會送入加護病房。」 "Now, for the first time, a treatment exists for these patients that not only reduces this risk of getting severely sick, but also has a multi-year beneficial effect after just a single injection. 「但現在，首次出現能幫助這些病患的療法。它不僅能降輕病情愈趨嚴重的可能，且在注射第一劑後，藥效也能保持多年。」 "Restoring the body's natural ability to break down fat particles in the blood, in order to prevent pancreatitis and excruciating abdominal pain suffered by patients, is what gene therapy is all about: curing disease at the genetic level." 「透過修復人體在血液中自然分解脂肪顆粒的能力，預防胰臟炎和難以忍受的腹部疼痛，這就是基因治療的目的－從遺傳層次治癒疾病。」 Dr Tomas Salmonson, from the agency's Committee, said the use of Glybera should be restricted to patients "with greatest need". 歐洲藥物管理局的委員沙蒙生醫生表示，Glybera應限用於「有極度需求」的病患身上。 China was the first country to officially sanction a gene therapy. 此外，中國為第一個官方通過基因療法的國家。 -- ※ 發信站: 批踢踢實業坊(ptt.cc) ◆ From: 219.85.198.143

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